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Active Ingredients

 

Camptothecin

Name: Camptothecin
Origin: Camptotheca acuminata Decne Bark
Spec: 99%
Appearance: Light-yellowpowder
CAS NO.: 7689-03-4
MW: 348.34
MF: C20H16N2O4
Formula: 
                   

Effect:
Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
camptothecin analogs exhibited remarkable anti-tumor and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication responsible for the winding / unwinding of the super-coiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA messages cannot occur so that the protein cannot be synthesized, which ultimately causes cell death.
Application of camptothecin in clinical settings is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs—either semi-synthetic or synthetic drugs based on camptothecin—have been applied as cancerous therapy such as topotecan and irinotecan, while others have obtained satisfying curative effects in clinical applications

Package: 1KG/bag 25KG/durm

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